Heterophyllin B
- CAS NO.：145459-19-4
- Empirical Formula: C40H58N8O8
- Molecular Weight: 778.94
- MDL number: MFCD22125018
- EINECS: 300-006-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Heterophyllin B?
Chemical properties
White crystal, easily soluble in methanol, derived from Radix Radix.
The Uses of Heterophyllin B
Taizishencyclopeptide B has the functions of invigorating qi and blood, invigorating body fluid and invigorating the spleen and stomach. And it was used for content determination/identification/pharmacological experiments, etc.
Biological Activity
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. It can be used in esophageal cancer research.
in vitro
Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups.Heterophyllin B (0 -50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells.
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Cell Viability Assay
| Cell Line: | ECA-109 cells |
| Concentration: | 5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM |
| Incubation Time: | 12, 24 and 48 hours |
| Result: | Decrease cell viability at high concentrations. |
Western Blot Analysis
| Cell Line: | ECA-109 cells |
| Concentration: | 0 μM, 10 μM, 25 μM, 50 μM |
| Incubation Time: | 6 hours |
| Result: | Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin. |
Properties of Heterophyllin B
| Boiling point: | 1159.7±65.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in DMSO |
| pka | 13.44±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for Heterophyllin B
Computed Descriptors for Heterophyllin B
New Products
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