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HomeProduct name listHepronicate

Hepronicate

Hepronicate Structural

What is Hepronicate?

Originator

Megrin,Yoshitomi,Japan,1972

Definition

ChEBI: Hepronicate is an organic molecular entity.

Manufacturing Process

In 50 ml of pyridine were dissolved 50 grams of nicotinic acid and 50 grams of p-toluene-sulfonyl chloride. While stirring, the mixture gradually became hot and colorless, and finally solidified. To the mixture was added dropwise a solution of 19 grams of 2-hexyl-2-(hydroxymethyl)-1,3-propanediol in 400 ml of pyridine at a temperature below 80°C. The mixture was heated at 115° to 125°C on an oil bath for 1 hour. After cooling, the mixture was poured into 300 ml of ice water, and extracted with toluene. The toluene layer was washed in sequence with water, aqueous sodium carbonate and water, dried over potassium carbonate, and then the toluene was distilled off. The oily residue was crystallized from ethanol to give 30 grams of 2-hexyl-2-(hydroxymethyl)- 1,3-propanediol trinicotinate, melting at 94° to 96°C. The yield was 59.5%.

Therapeutic Function

Vasodilator

Properties of Hepronicate

Melting point: 94-96°
storage temp.  Store at -20°C
solubility  Soluble in DMSO
form  Solid
color  White to off-white

Safety information for Hepronicate

Computed Descriptors for Hepronicate

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