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HomeProduct name listHEMICHOLINIUM-3

HEMICHOLINIUM-3

  • CAS NO.:312-45-8
  • Empirical Formula: C24H34N2O4.2Br
  • Molecular Weight: 574.351
  • MDL number: MFCD00011978
  • EINECS: 206-227-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
HEMICHOLINIUM-3 Structural

What is HEMICHOLINIUM-3?

The Uses of HEMICHOLINIUM-3

Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.

The Uses of HEMICHOLINIUM-3

Acetylcholine stores depletor

The Uses of HEMICHOLINIUM-3

Research tool as cholinergic probe, to deplete acetylcholine stores.

Biochem/physiol Actions

Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.

Properties of HEMICHOLINIUM-3

Melting point: 180°; mp 226- 228° (dec)
storage temp.  Store at -20°C
solubility  ethanol: 1.3 mg/mL
form  solid
color  white
Water Solubility  Water : 33.33 mg/mL (58.03 mM; Need ultrasonic)
Merck  13,4660
BRN  5704458
EPA Substance Registry System Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide (312-45-8)

Safety information for HEMICHOLINIUM-3

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for HEMICHOLINIUM-3

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