HEMATOPORPHYRIN DIHYDROCHLORIDE
- CAS NO.：17696-69-4
- Empirical Formula: C34H39ClN4O6
- Molecular Weight: 635.16
- MDL number: MFCD00013470
- EINECS: 241-699-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 20:20:38
What is HEMATOPORPHYRIN DIHYDROCHLORIDE?
Description
Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.
The Uses of HEMATOPORPHYRIN DIHYDROCHLORIDE
Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate.
Properties of HEMATOPORPHYRIN DIHYDROCHLORIDE
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Very Dark Red |
| Water Solubility | Insoluble in water. Soluble in pyridine (5%). |
| Merck | 14,4636 |
| BRN | 78957 |
| Stability: | Hygroscopic |
| EPA Substance Registry System | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
Safety information for HEMATOPORPHYRIN DIHYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for HEMATOPORPHYRIN DIHYDROCHLORIDE
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