HC≡C-CH2-PEG3-SH
- CAS NO.：1412905-18-0
- Empirical Formula: C9H16O3S
- Molecular Weight: 204.29
- MDL number: MFCD31747070
- Update Date: 2023-02-23 14:24:01
What is HC≡C-CH2-PEG3-SH?
Biological Activity
Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HC≡C-CH2-PEG3-SH
| Boiling point: | 286.2±30.0 °C(Predicted) |
| Density | 1.053±0.06 g/cm3(Predicted) |
| pka | 9?+-.0.10(Predicted) |
Safety information for HC≡C-CH2-PEG3-SH
Computed Descriptors for HC≡C-CH2-PEG3-SH
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