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HomeProduct name listHARMINE HYDROCHLORIDE

HARMINE HYDROCHLORIDE

Synonym(s):7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride

  • CAS NO.:343-27-1
  • Empirical Formula: C13H13ClN2O
  • Molecular Weight: 248.71
  • MDL number: MFCD00012641
  • EINECS: 206-443-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-10 17:26:08
HARMINE HYDROCHLORIDE Structural

What is HARMINE HYDROCHLORIDE?

Description

Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50?= 8 μM).1?Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50‘s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3?Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC’s) possibly via inhibition of Akt phosphorylation.4?Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5?Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6

Chemical properties

yellow to slightly green crystalline powder

The Uses of HARMINE HYDROCHLORIDE

Harmine Monohydrochloride is an anti-viral agents for the treatment of EV71 infection. It inhibits enterovirus 71 replication by targeting NF-κB pathway.

What are the applications of Application

Harmine hydrochloride is a fluorescent harmala alkaloid and CNS stimulant found in Peganum harmala.

Purification Methods

The hydrate crystallises as fluorescent crystals from water. The anhydrous salt has m 319o. [Beilstein 23/12 V 237.]

References

1) Wouters (1998)?Structural Aspects of Monoamine Oxidase and its Reversible Inhibition?Current Medicinal Chemistry,?5?137 2) Seifert?et al. (2008)?DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine; FEBS J.,?275?6268 3) Gockler?et al. (2009)?Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite outgrowth; FEBS J.,?276?6324 4) Liu?et al. (2013)?Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma; J .Neurooncol.,?112?39 5) Patel?et al. (2012)?A review on medical importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid ‘Harmine’; Asian Pac. J. Trop. Biomed.,?2?660 6) Yoneazwa?et al. (2011)?Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo; Eur. J. Pharmacol.,?650?511

Properties of HARMINE HYDROCHLORIDE

Melting point: 265-270°C
storage temp.  2-8°C
solubility  Soluble in Water (up to 25 mg/ml).
form  powder
color  off-white to pale green
Merck  14,4616
Stability: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference 343-27-1(CAS DataBase Reference)
EPA Substance Registry System Harmine hydrochloride (343-27-1)

Safety information for HARMINE HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for HARMINE HYDROCHLORIDE

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