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HomeProduct name listH2N-PEG5-CH2COOH

H2N-PEG5-CH2COOH

H2N-PEG5-CH2COOH Structural

What is H2N-PEG5-CH2COOH?

Biological Activity

Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Properties of H2N-PEG5-CH2COOH

Boiling point: 434.2±40.0 °C(Predicted)
Density  1.150±0.06 g/cm3(Predicted)
solubility  DMSO : 20 mg/mL (67.72 mM; ultrasonic and warming and heat to 60°C)
form  Solid
pka 3.39±0.10(Predicted)
color  White to off-white

Safety information for H2N-PEG5-CH2COOH

Computed Descriptors for H2N-PEG5-CH2COOH

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