H2N-PEG5-CH2COOH
- CAS NO.：141282-35-1
- Empirical Formula: C12H25NO7
- Molecular Weight: 295.33
- MDL number: MFCD27977526
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is H2N-PEG5-CH2COOH?
Biological Activity
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Properties of H2N-PEG5-CH2COOH
| Boiling point: | 434.2±40.0 °C(Predicted) |
| Density | 1.150±0.06 g/cm3(Predicted) |
| solubility | DMSO : 20 mg/mL (67.72 mM; ultrasonic and warming and heat to 60°C) |
| form | Solid |
| pka | 3.39±0.10(Predicted) |
| color | White to off-white |
Safety information for H2N-PEG5-CH2COOH
Computed Descriptors for H2N-PEG5-CH2COOH
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