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HomeProduct name listAmino-PEG10-alcohol

Amino-PEG10-alcohol

  • CAS NO.:129449-09-8
  • Empirical Formula: C20H43NO10
  • Molecular Weight: 457.56
  • MDL number: MFCD28385478
  • Update Date: 2024-03-22 17:12:53
Amino-PEG10-alcohol Structural

What is Amino-PEG10-alcohol?

Description

Amino-PEG10-alcohol is a highly water soluble PEG reagent. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Biological Activity

Amino-PEG10-OH is a non-cleavable 10-unit PEG-ADC linker for antibody drug-drug (ADC) synthesis. It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Properties of Amino-PEG10-alcohol

Boiling point: 533.3±45.0 °C(Predicted)
Density  1.096±0.06 g/cm3(Predicted)
pka 14.36±0.10(Predicted)

Safety information for Amino-PEG10-alcohol

Computed Descriptors for Amino-PEG10-alcohol

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