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HomeProduct name listH-GLY-PRO-ARG-PRO-NH2

H-GLY-PRO-ARG-PRO-NH2

Synonym(s):Glycine-Proline-Arginine-Proline amide;Glycyl-L-prolyl-L-arginyl-L-prolinamide;GPRP amide

H-GLY-PRO-ARG-PRO-NH2 Structural

What is H-GLY-PRO-ARG-PRO-NH2?

The Uses of H-GLY-PRO-ARG-PRO-NH2

Gly-Pro-Arg-Pro amide has been used-

  • as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin
  • for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice
  • during preparation of human soluble fibrin, to block the polymerization of soluble fibrin

General Description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

Properties of H-GLY-PRO-ARG-PRO-NH2

storage temp.  -20°C

Safety information for H-GLY-PRO-ARG-PRO-NH2

Computed Descriptors for H-GLY-PRO-ARG-PRO-NH2

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