H-1152Glycyl, Dihydrochloride
- CAS NO.:913844-45-8
- Empirical Formula: C18H26Cl2N4O3S
- Molecular Weight: 0
- MDL number: MFCD09971082
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is H-1152Glycyl, Dihydrochloride?
Chemical properties
Pale-Yellow Solid
The Uses of H-1152Glycyl, Dihydrochloride
A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis.
What are the applications of Application
Rho Kinase Inhibitor IV is a glycyl analog of Rho-Kinase Inhibitor
Biological Activity
Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride ((S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride ) that displays improved ROCKII selectivity. IC 50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μ M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
storage
room temperature (desiccate)
Properties of H-1152Glycyl, Dihydrochloride
Melting point: | 190-192°C |
storage temp. | Refrigerator |
solubility | Methanol (Slightly), Water (Slightly) |
form | Solid |
color | Pale Yellow to Beige |
Stability: | Hygroscopic |
CAS DataBase Reference | 913844-45-8 |
Safety information for H-1152Glycyl, Dihydrochloride
Computed Descriptors for H-1152Glycyl, Dihydrochloride
New Products
Tubulysin I (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2,2-diethoxyethanethioamide 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropylamine hydrochloride Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 4,4-DIFLUOROPIPERIDINE 2,2-Difluoropropanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
FASUDIL
H-1152Glycyl, Dihydrochloride
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