H-1152Glycyl, Dihydrochloride

Chemical properties

Pale-Yellow Solid

The Uses of H-1152Glycyl, Dihydrochloride

A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis.

What are the applications of Application

Rho Kinase Inhibitor IV is a glycyl analog of Rho-Kinase Inhibitor

Biological Activity

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride ((S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride ) that displays improved ROCKII selectivity. IC 50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μ M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

storage

room temperature (desiccate)