GYKI 52466 HYDROCHLORIDE
Synonym(s):1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
- CAS NO.:102771-26-6
- Empirical Formula: C17H16ClN3O2
- Molecular Weight: 329.78
- MDL number: MFCD00885518
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is GYKI 52466 HYDROCHLORIDE?
The Uses of GYKI 52466 HYDROCHLORIDE
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment.
What are the applications of Application
GYKI 52466 hydrochloride is a selective non-competitive allosteric AMPA receptor antagonist
Definition
ChEBI: GYKI 52466 is a benzodiazepine.
Biological Activity
Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ .
storage
room temperature (desiccate)
Properties of GYKI 52466 HYDROCHLORIDE
Boiling point: | 472.8±45.0 °C(Predicted) |
Density | 1.39 |
storage temp. | Desiccate at RT |
solubility | DMSO: 0.39 mg/mL |
form | solid |
pka | 8.14±0.20(Predicted) |
color | yellow |
Safety information for GYKI 52466 HYDROCHLORIDE
Computed Descriptors for GYKI 52466 HYDROCHLORIDE
New Products
Tubulysin G Tubulysin C Tubulysin H Tubulysin M Potassium HMDS (1.0 M in THF) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 4,4-DIFLUOROCYCLOHEXANAMINE tetrahydro-4-methyl-2H-pyran 1-(1,1-Difluoroethyl)-2-fluorobenzene CYCLOBUTYLAMINE HYDROCHLORIDE 3-N-BOC-(S)-AMINO BUTYRONITRILE Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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