GW583340 DIHYDROCHLORIDE
- CAS NO.:388082-81-3
- Empirical Formula: C28H25ClFN5O3S2
- Molecular Weight: 598.11
- MDL number: MFCD07370137
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:38
What is GW583340 DIHYDROCHLORIDE?
What are the applications of Application
GW 583340 dihydrochloride is a potent inhibitor of EGFR/Neu (EGFR/ErbB2)
Definition
ChEBI: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-4-thiazolyl]-4-quinazolinamine is a member of quinazolines.
Biological Activity
Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.
Properties of GW583340 DIHYDROCHLORIDE
Melting point: | 259.8-262.4 °C(lit.) |
storage temp. | 2-8°C |
solubility | DMSO: 9 mg/mL |
form | solid |
Safety information for GW583340 DIHYDROCHLORIDE
Computed Descriptors for GW583340 DIHYDROCHLORIDE
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
(2-Thiazolyl)methylamine
GW583340 DIHYDROCHLORIDE
4-BENZYLOXY-3-CHLOROANILINE 96
3-Chloro-4-(3-fluorobenzyloxy)aniline
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