GUANIDINYL NALTRINDOLE
Synonym(s):GNTI
- CAS NO.：219655-57-9
- Empirical Formula: C27H29N5O3
- Molecular Weight: 471.558
- MDL number: MFCD03788471
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is GUANIDINYL NALTRINDOLE?
The Uses of GUANIDINYL NALTRINDOLE
5′-Guanidinonaltrindole di(trifluoroacetate) Salt is a selective opioid receptor antagonist. It has also been utilized to develop fluorescent methods to identify phosphopantetheinyl transferase inhibitors.
The Uses of GUANIDINYL NALTRINDOLE
5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
- to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
- to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
- to validate its inhibitory actions on Akt kinase activities
What are the applications of Application
5′-Guanidinonaltrindole di(trifluoroacetate) is a selective KOR (κopioid receptor) antagonist
Biochem/physiol Actions
5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.
Properties of GUANIDINYL NALTRINDOLE
| storage temp. | 2-8°C |
| solubility | H2O: soluble30mg/mL |
| form | solid |
Safety information for GUANIDINYL NALTRINDOLE
Computed Descriptors for GUANIDINYL NALTRINDOLE
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