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HomeProduct name listGUANETHIDINE HEMISULFATE

GUANETHIDINE HEMISULFATE

  • CAS NO.:60-02-6
  • Empirical Formula: C10H22N4.1/2H2O4S
  • Molecular Weight: 494.7
  • MDL number: MFCD00079332
  • EINECS: 200-452-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-09 09:30:26
GUANETHIDINE HEMISULFATE Structural

What is GUANETHIDINE HEMISULFATE?

Chemical properties

White Solid

Originator

Ismelin,Ciba,US,1960

The Uses of GUANETHIDINE HEMISULFATE

Antihypertensive; antiglaucoma

What are the applications of Application

Guanethidine Hemisulfate is a compound also known as 2-(1′-Azacyclooctyl)ethylguanidine Hemisulfate

Definition

ChEBI: A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.

Manufacturing Process

13.6 grams of chloroacetyl guanide is added while stirring to a solution of 22.6 grams of heptamethylene imine in 200 ml of benzene. After warming for 1 hour, and then cooling, the solution is filtered and the filtrate concentrated under reduced pressure. The residue, containing the 2-(1-N,N-heptamethylene-imino)-aceticacid guanide, is suspended in tetrahydrofuran and added to a refluxing solution of 6 grams of lithium aluminum hydride in tetrahydrofuran. After completion of the reaction, the excess of lithium aluminum hydride is decomposed by adding water, then aqueous sodium hydroxide. The solid material is filtered off, the filtrate is acidified with sulfuric acid and the 2-(1-N,N-heptamethylene-imino)-ethyl-guanidine sulfate can be recovered and recrystallized from aqueous ethanol, MP 276° to 281°C (with decomposition).

Therapeutic Function

Antihypertensive

Properties of GUANETHIDINE HEMISULFATE

Melting point: 255-265°C
Density  1.1052 (rough estimate)
refractive index  1.7400 (estimate)
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility  Methanol (Slightly), Water (Slightly)
form  Solid
color  White
Merck  4560
Stability: Hygroscopic
CAS DataBase Reference 60-02-6

Safety information for GUANETHIDINE HEMISULFATE

Computed Descriptors for GUANETHIDINE HEMISULFATE

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