GUANETHIDINE HEMISULFATE
- CAS NO.:60-02-6
- Empirical Formula: C10H22N4.1/2H2O4S
- Molecular Weight: 494.7
- MDL number: MFCD00079332
- EINECS: 200-452-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 09:30:26
What is GUANETHIDINE HEMISULFATE?
Chemical properties
White Solid
Originator
Ismelin,Ciba,US,1960
The Uses of GUANETHIDINE HEMISULFATE
Antihypertensive; antiglaucoma
What are the applications of Application
Guanethidine Hemisulfate is a compound also known as 2-(1′-Azacyclooctyl)ethylguanidine Hemisulfate
Definition
ChEBI: A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Manufacturing Process
13.6 grams of chloroacetyl guanide is added while stirring to a solution of 22.6 grams of heptamethylene imine in 200 ml of benzene. After warming for 1 hour, and then cooling, the solution is filtered and the filtrate concentrated under reduced pressure. The residue, containing the 2-(1-N,N-heptamethylene-imino)-aceticacid guanide, is suspended in tetrahydrofuran and added to a refluxing solution of 6 grams of lithium aluminum hydride in tetrahydrofuran. After completion of the reaction, the excess of lithium aluminum hydride is decomposed by adding water, then aqueous sodium hydroxide. The solid material is filtered off, the filtrate is acidified with sulfuric acid and the 2-(1-N,N-heptamethylene-imino)-ethyl-guanidine sulfate can be recovered and recrystallized from aqueous ethanol, MP 276° to 281°C (with decomposition).
Therapeutic Function
Antihypertensive
Properties of GUANETHIDINE HEMISULFATE
Melting point: | 255-265°C |
Density | 1.1052 (rough estimate) |
refractive index | 1.7400 (estimate) |
storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
solubility | Methanol (Slightly), Water (Slightly) |
form | Solid |
color | White |
Merck | 4560 |
Stability: | Hygroscopic |
CAS DataBase Reference | 60-02-6 |
Safety information for GUANETHIDINE HEMISULFATE
Computed Descriptors for GUANETHIDINE HEMISULFATE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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