GS 39783
Synonym(s):GS-39783;N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine;N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
- CAS NO.:39069-52-8
- Empirical Formula: C15H23N5O2S
- Molecular Weight: 337.44
- MDL number: MFCD06201849
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is GS 39783?
The Uses of GS 39783
GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex.
What are the applications of Application
GS 39783 is a positive modulator at GABAB receptors
Definition
ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide.
Biological Activity
Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
storage
Store at RT
Properties of GS 39783
storage temp. | Store at RT |
solubility | DMSO: ~8 mg/mL |
form | powder |
color | yellow |
Safety information for GS 39783
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GS 39783
New Products
Tubulysin D Tubulysin A Tubulysin E Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol 4,4-DIFLUOROCYCLOHEXANAMINE 3-Aminocyclobutanone hydrochloride Fuel shell Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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