GS 39783

Synonym(s):GS-39783;N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine;N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine

CAS NO.：39069-52-8
Empirical Formula: C15H23N5O2S
Molecular Weight: 337.44
MDL number: MFCD06201849
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 15:28:16

What is GS 39783?

The Uses of GS 39783

GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex.

What are the applications of Application

GS 39783 is a positive modulator at GABAB receptors

Definition

ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide.

Biological Activity

Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.

storage

Store at RT

Properties of GS 39783

storage temp.	Store at RT
solubility	DMSO: ~8 mg/mL
form	powder
color	yellow

Safety information for GS 39783

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.