GS 39783
Synonym(s):GS-39783;N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine;N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
- CAS NO.：39069-52-8
- Empirical Formula: C15H23N5O2S
- Molecular Weight: 337.44
- MDL number: MFCD06201849
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is GS 39783?
The Uses of GS 39783
GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex.
What are the applications of Application
GS 39783 is a positive modulator at GABAB receptors
Definition
ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide.
Biological Activity
Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
storage
Store at RT
Properties of GS 39783
| storage temp. | Store at RT |
| solubility | DMSO: ~8 mg/mL |
| form | powder |
| color | yellow |
Safety information for GS 39783
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GS 39783
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1,1’-CARBONYLDIIMIDAZOLE DIETHYL AMINOMALONATE HYDROCHLORIDE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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