GRAMICIDIN A
Synonym(s):gA;Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem
- CAS NO.:11029-61-1
- Empirical Formula: C99H140N20O17
- Molecular Weight: 1882.29
- MDL number: MFCD00466944
- EINECS: 234-259-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is GRAMICIDIN A?
The Uses of GRAMICIDIN A
Gramicidin A is an effective antibiotic against Gram positive organisms.
What are the applications of Application
Gramicidin A is an effective and naturally occurring antibiotic against Gram positive organisms, used to study membrane channels.
Purification Methods
Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]
Properties of GRAMICIDIN A
storage temp. | 2-8°C |
solubility | ethanol: soluble |
form | White to off-white solid |
color | colorless or white |
BRN | 6461131 |
Safety information for GRAMICIDIN A
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for GRAMICIDIN A
New Products
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