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HomeProduct name listGRAMICIDIN A

GRAMICIDIN A

Synonym(s):gA;Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem

  • CAS NO.:11029-61-1
  • Empirical Formula: C99H140N20O17
  • Molecular Weight: 1882.29
  • MDL number: MFCD00466944
  • EINECS: 234-259-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
GRAMICIDIN A Structural

What is GRAMICIDIN A?

The Uses of GRAMICIDIN A

Gramicidin A is an effective antibiotic against Gram positive organisms.

What are the applications of Application

Gramicidin A is an effective and naturally occurring antibiotic against Gram positive organisms, used to study membrane channels.

Purification Methods

Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]

Properties of GRAMICIDIN A

storage temp.  2-8°C
solubility  ethanol: soluble
form  White to off-white solid
color  colorless or white
BRN  6461131

Safety information for GRAMICIDIN A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for GRAMICIDIN A

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