GNE-3511
- CAS NO.：1496581-76-0
- Empirical Formula: C23H26F2N6O
- Molecular Weight: 440.49
- MDL number: MFCD28502215
- Update Date: 2024-11-01 18:44:47
What is GNE-3511?
The Uses of GNE-3511
GNE-3511 is a potent and selective dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. GNE-3511 displays concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. GNE-3511 displays protection of primary neurons in an in vitro axon degeneration assay as well as activity in the mouse models of glaucoma/optic neuropathy (optic nerve crush) and Parkinson’s disease (MPTP) after oral dosing.
Properties of GNE-3511
| Boiling point: | 579.0±50.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM) Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) |
| form | A crystalline solid |
| pka | 7.23±0.40(Predicted) |
| color | Light yellow to yellow |
Safety information for GNE-3511
Computed Descriptors for GNE-3511
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