Glycyl-glycyl-glycine

Chemical properties

White prismatic crystals or powder cannot coexist with strong oxidizing agents, aluminum, copper, copper alloy, and nickel. Glycyl-glycyl-glycine has a strong complexing ability and can form stable chelates with different metal ions due to its small molecule size and ability to provide four coordination bonds for metal ions.

The Uses of Glycyl-glycyl-glycine

Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator.

Definition

ChEBI: Glycyl-glycyl-glycine is a tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. It is a tautomer of a Gly-Gly-Gly zwitterion.

What are the applications of Application

Glycyl-glycyl-glycine is commonly used in the food, pharmaceutical, and cosmetic industries as an ingredient in skin and hair care products. It is also used as a dietary supplement due to its ability to improve digestion and promote the growth of healthy gut bacteria.

General Description

Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.

Biochem/physiol Actions

Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.

Purification Methods

Crystallise triglycine from H2O or H2O/EtOH and dry it at 110o. [Yakel & Hughes Acta Cryst 5 847 1952, Lenel et al. Acta Cryst 3 313 1952, Holley & Holley J Am Chem Soc 74 3072 1952, Beilstein 4 III 1198, 4 IV 2469.]