GLY-ARG-GLY-ASP-SER
Synonym(s):GRGDS;H-Gly-Arg-Gly-Asp-Ser-OH - CAS 96426-21-0 - Calbiochem
- CAS NO.：96426-21-0
- Empirical Formula: C17H30N8O9
- Molecular Weight: 490.47
- MDL number: MFCD00076459
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is GLY-ARG-GLY-ASP-SER?
The Uses of GLY-ARG-GLY-ASP-SER
Gly-Arg-Gly-Asp-Ser has been used-
- as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice
- for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1+ progenitor cell differentiation into SMCs (smooth muscle cells)
- as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin
- for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus
General Description
Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.
Biochem/physiol Actions
Antagonist of integrin function
Properties of GLY-ARG-GLY-ASP-SER
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO : 100 mg/mL (203.89 mM);Water : 33.33 mg/mL (67.96 mM) |
| form | White to off-white lyophilized solid |
| pka | 2.85±0.10(Predicted) |
| color | White to off-white |
Safety information for GLY-ARG-GLY-ASP-SER
Computed Descriptors for GLY-ARG-GLY-ASP-SER
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