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HomeProduct name listGLY-ARG-GLY-ASP-SER

GLY-ARG-GLY-ASP-SER

Synonym(s):GRGDS;H-Gly-Arg-Gly-Asp-Ser-OH - CAS 96426-21-0 - Calbiochem

GLY-ARG-GLY-ASP-SER Structural

What is GLY-ARG-GLY-ASP-SER?

The Uses of GLY-ARG-GLY-ASP-SER

Gly-Arg-Gly-Asp-Ser has been used-

  • as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice
  • for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1+ progenitor cell differentiation into SMCs (smooth muscle cells)
  • as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin
  • for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus

General Description

Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.

Biochem/physiol Actions

Antagonist of integrin function

Properties of GLY-ARG-GLY-ASP-SER

Density  1.66±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO : 100 mg/mL (203.89 mM);Water : 33.33 mg/mL (67.96 mM)
form  White to off-white lyophilized solid
pka 2.85±0.10(Predicted)
color  White to off-white

Safety information for GLY-ARG-GLY-ASP-SER

Computed Descriptors for GLY-ARG-GLY-ASP-SER

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