GLPG-1690
- CAS NO.：1628260-79-6
- Empirical Formula: C30H33FN8O2S
- Molecular Weight: 588.7
- MDL number: MFCD31544330
- Update Date: 2024-11-01 18:44:47
What is GLPG-1690?
The Uses of GLPG-1690
GLPG1690 is a selective autotaxin inhibitor discovered by Galapagos, with potential application in idiopathic pulmonary disease (IPF). In a Phase 1 study in healthy human volunteers, GLPG1690 demonstrated favorable safety and tolerability, as well as a strong pharmacodynamic signal implying target engagement.
Properties of GLPG-1690
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:70.84(Max Conc. mg/mL);120.32(Max Conc. mM) Ethanol:4.0(Max Conc. mg/mL);6.79(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.72±0.20(Predicted) |
| color | White to off-white |
Safety information for GLPG-1690
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GLPG-1690
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