GITOXIGENIN
- CAS NO.:545-26-6
- Empirical Formula: C23H34O5
- Molecular Weight: 390.51
- MDL number: MFCD00021174
- EINECS: 208-886-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is GITOXIGENIN?
Chemical properties
light yellow flakes
The Uses of GITOXIGENIN
Gitoxigenin is a related compound of Digitoxigenin, which has been used in a study to assess its stereochemical effects in cancer cytotoxicity. Digitoxigenin has also been used in a study to investigate the advantage of gold(I)-catalyzed glycosidation of glycosyl o-alkyl benzoates to assemble digitoxin.
What are the applications of Application
Gitoxigenin is a 16β-substituted digitoxigenin
Definition
ChEBI: Gitoxigenin is a 3beta-hydroxy steroid, a 14beta-hydroxy steroid and a 16beta-hydroxy steroid. It derives from a hydride of a 5beta-cardanolide.
Biochem/physiol Actions
Structure-activity relationships for 16β-substituted digitoxigenins as inhibitors of Na+/K+ ATPases.
Purification Methods
Recrystallisation of gitoxigenin from aqueous EtOH produces plates of the sesquihydrate which dehydrate on drying at 100o in vacuo. It also recrystallises from Me2CO/MeOH and from EtOAc (the crystals contain 1 mol of EtOAc) with [] D +24.8o (c 1, dioxane). It has UV with max at 310, 485 and 520nm in 96% H2SO4. On heating with ethanolic HCl it yields digitaligenin with loss of H2O. [Smith J Chem Soc 23 1931, Beilstein 8 IV 2456.]
Properties of GITOXIGENIN
Melting point: | ~230 °C |
Boiling point: | 435.71°C (rough estimate) |
Density | 1.0639 (rough estimate) |
refractive index | 1.6120 (estimate) |
storage temp. | −20°C |
pka | 14.56±0.70(Predicted) |
Merck | 13,4445 |
Safety information for GITOXIGENIN
Computed Descriptors for GITOXIGENIN
New Products
Tubulysin B Tubulysin G (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Diethyl Aluminium Cyanide (1.0 M in Toluene) 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE tetrahydro-4-methyl-2H-pyran 2H-Pyran, 4-ethynyltetrahydro- 1-(1,1-Difluoroethyl)-2-fluorobenzene 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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