GALLEIN

Synonym(s):4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate;Gβγ Modulator II, Gallein - CAS 2103-64-2 - Calbiochem

CAS NO.：2103-64-2
Empirical Formula: C20H12O7
Molecular Weight: 364.31
MDL number: MFCD00041839
EINECS: 218-272-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 08:26:49

What is GALLEIN?

The Uses of GALLEIN

Gallein inhibits neutrophil chemotaxis and inflammation, via the disruption of G protein βγ subunit signaling.

What are the applications of Application

Gallein is an inhibitor of Gβγ-dependent cellular activities which binds to Gβγ with high affinity

Definition

ChEBI: A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.

Preparation

3,4,5-Trihydroxybenzoic acid or Benzene-1,2,3-triol?and Phthalic anhydride?in 190 ~ 200 ℃ reaction (namely GALLEIN), and then into sodium salt namely Alizarine Violet.

Biological Activity

Inhibitor of G protein β γ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

storage

Store at -20°C

Properties and Applications

blue light purple. Free acid soluble in hot water for the big red, soluble in hot ethanol for red light brown. In concentrated sulfuric acid to red light yellow, after dilution with fluorescence red yellow precipitation. Dye aqueous solution to join sodium hydroxide as blue.

Standard	Ironing Fastness	Light Fastness	Fulling		Persperation Fastness	Soaping	Water
Standard	Ironing Fastness	Light Fastness	Alkali	Acid	Persperation Fastness	Soaping	Water
ISO	4-5	4	4		5	4	5
AATCC	5	4-5	5		5	5

Properties of GALLEIN

Melting point:	>300°C
Boiling point:	389.44°C (rough estimate)
Density	1.2392 (rough estimate)
refractive index	1.6120 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Solubility Almost insoluble in water, benzene, chloroform; soluble in ethanol, acetone
pka	5.99(at 25℃)
Colour Index	45445
form	powder
color	Brownish-red
PH Range	Yellow (3.8) to rose-red (6.6);Pink (10.6) to violet (13.0)
λmax	526nm
Merck	14,4344
Stability:	Hygroscopic
Major Application	Organic light emitting devices (OLED), treatment of cancer cells, diagnosis and treatment of amyloidosis, cancer chemo preventive activity, inhibition of influenza virus, semiconductors, photoresists, lithographic printing plates, method for ozone determination, treatment of wastewater, determination of silver, nail polish, monitoring sterilization, determination of proteins, induce apoptosis in cancer cells, treatement of cancer cells, antiHIV agent, cancer chemopreventive activity, drug design
CAS DataBase Reference	2103-64-2
EPA Substance Registry System	Gallein (2103-64-2)

Safety information for GALLEIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.