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HomeProduct name listGALLEIN

GALLEIN

Synonym(s):4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate;Gβγ Modulator II, Gallein - CAS 2103-64-2 - Calbiochem

  • CAS NO.:2103-64-2
  • Empirical Formula: C20H12O7
  • Molecular Weight: 364.31
  • MDL number: MFCD00041839
  • EINECS: 218-272-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-17 16:00:36
GALLEIN Structural

What is GALLEIN?

The Uses of GALLEIN

Gallein inhibits neutrophil chemotaxis and inflammation, via the disruption of G protein βγ subunit signaling.

What are the applications of Application

Gallein is an inhibitor of Gβγ-dependent cellular activities which binds to Gβγ with high affinity

Definition

ChEBI: A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.

Preparation

3,4,5-Trihydroxybenzoic acid or Benzene-1,2,3-triol?and Phthalic anhydride?in 190 ~ 200 ℃ reaction (namely GALLEIN), and then into sodium salt namely Alizarine Violet.

Biological Activity

Inhibitor of G protein β γ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

storage

Store at -20°C

Properties and Applications

blue light purple. Free acid soluble in hot water for the big red, soluble in hot ethanol for red light brown. In concentrated sulfuric acid to red light yellow, after dilution with fluorescence red yellow precipitation. Dye aqueous solution to join sodium hydroxide as blue.

Standard Ironing Fastness Light Fastness Fulling Persperation Fastness Soaping Water
Alkali Acid
ISO 4-5 4 4 5 4 5
AATCC 5 4-5 5 5 5

Properties of GALLEIN

Melting point: >300°C
Boiling point: 389.44°C (rough estimate)
Density  1.2392 (rough estimate)
refractive index  1.6120 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Solubility Almost insoluble in water, benzene, chloroform; soluble in ethanol, acetone
pka 5.99(at 25℃)
Colour Index  45445
form  powder
color  Brownish-red
PH Range Yellow (3.8) to rose-red (6.6);Pink (10.6) to violet (13.0)
λmax 526nm
Merck  14,4344
Stability: Hygroscopic
Major Application Organic light emitting devices (OLED), treatment of cancer cells, diagnosis and treatment of amyloidosis, cancer chemo preventive activity, inhibition of influenza virus, semiconductors, photoresists, lithographic printing plates, method for ozone determination, treatment of wastewater, determination of silver, nail polish, monitoring sterilization, determination of proteins, induce apoptosis in cancer cells, treatement of cancer cells, antiHIV agent, cancer chemopreventive activity, drug design
CAS DataBase Reference 2103-64-2
EPA Substance Registry System Gallein (2103-64-2)

Safety information for GALLEIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for GALLEIN

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