GALLEIN
Synonym(s):4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate;Gβγ Modulator II, Gallein - CAS 2103-64-2 - Calbiochem
- CAS NO.：2103-64-2
- Empirical Formula: C20H12O7
- Molecular Weight: 364.31
- MDL number: MFCD00041839
- EINECS: 218-272-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is GALLEIN?
The Uses of GALLEIN
Gallein inhibits neutrophil chemotaxis and inflammation, via the disruption of G protein βγ subunit signaling.
What are the applications of Application
Gallein is an inhibitor of Gβγ-dependent cellular activities which binds to Gβγ with high affinity
Definition
ChEBI: A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.
Preparation
3,4,5-Trihydroxybenzoic acid or Benzene-1,2,3-triol?and Phthalic anhydride?in 190 ~ 200 ℃ reaction (namely GALLEIN), and then into sodium salt namely Alizarine Violet.
Biological Activity
Inhibitor of G protein β γ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
storage
Store at -20°C
Properties and Applications
blue light purple. Free acid soluble in hot water for the big red, soluble in hot ethanol for red light brown. In concentrated sulfuric acid to red light yellow, after dilution with fluorescence red yellow precipitation. Dye aqueous solution to join sodium hydroxide as blue.
| Standard | Ironing Fastness | Light Fastness | Fulling | Persperation Fastness | Soaping | Water | |
| Alkali | Acid | ||||||
| ISO | 4-5 | 4 | 4 | 5 | 4 | 5 | |
| AATCC | 5 | 4-5 | 5 | 5 | 5 | ||
Properties of GALLEIN
| Melting point: | >300°C |
| Boiling point: | 389.44°C (rough estimate) |
| Density | 1.2392 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Solubility Almost insoluble in water, benzene, chloroform; soluble in ethanol, acetone |
| pka | 5.99(at 25℃) |
| Colour Index | 45445 |
| form | powder |
| color | Brownish-red |
| PH Range | Yellow (3.8) to rose-red (6.6);Pink (10.6) to violet (13.0) |
| λmax | 526nm |
| Merck | 14,4344 |
| Stability: | Hygroscopic |
| Major Application | Organic light emitting devices (OLED), treatment of cancer cells, diagnosis and treatment of amyloidosis, cancer chemo preventive activity, inhibition of influenza virus, semiconductors, photoresists, lithographic printing plates, method for ozone determination, treatment of wastewater, determination of silver, nail polish, monitoring sterilization, determination of proteins, induce apoptosis in cancer cells, treatement of cancer cells, antiHIV agent, cancer chemopreventive activity, drug design |
| CAS DataBase Reference | 2103-64-2 |
| EPA Substance Registry System | Gallein (2103-64-2) |
Safety information for GALLEIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GALLEIN
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