FR 122047 HYDROCHLORIDE

Synonym(s):1-[(4,5-Bis(4-methoxyphenyl)-2-thiazoyl)carbonyl]-4-methylpiperazine hydrochloride;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

CAS NO.：130717-51-0
Empirical Formula: C23H26ClN3O3S
Molecular Weight: 459.99
MDL number: MFCD00925604
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-20 16:43:00

What is FR 122047 HYDROCHLORIDE?

Description

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

The Uses of FR 122047 HYDROCHLORIDE

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

What are the applications of Application

FR 122047 hydrochloride is a highly selective Cox-1 inhibitor

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .