FOLINIC ACID CALCIUM SALT PENTAHYDRATE
- CAS NO.：41927-89-3
- Empirical Formula: C20H31CaN7O12
- Molecular Weight: 601.58
- MDL number: MFCD00149465
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 15:14:41
What is FOLINIC ACID CALCIUM SALT PENTAHYDRATE?
The Uses of FOLINIC ACID CALCIUM SALT PENTAHYDRATE
Anti-anemic (folate deficiency); antidote (to folic acid antagonists).
brand name
Wellcovorin (GlaxoSmithKline).
Clinical Use
Folinic acid rescue
Enhancement of 5-fluorouracil cytotoxicity in
advanced colorectal cancer
Folate deficiency
Drug interactions
Potentially hazardous interactions with other drugs
Should not be administered simultaneously with a
folic acid antagonist as this may nullify the effect of
the antagonist.
Cytotoxics: avoid with panitumumab and raltitrexed.
Metabolism
Folinic acid is a racemate where the L-form (L-5-
formyl-tetrahydrofolate, L-5-formyl-THF), is the active
enantiomer. The major metabolic product of folinic acid
is 5-methyl-tetrahydrofolic acid (5-methyl-THF) which
is predominantly produced in the liver and intestinal
mucosa.
80-90% with the urine (5- and 10-formyltetrahydrofolates
inactive metabolites), 5-8% with the
faeces.
Properties of FOLINIC ACID CALCIUM SALT PENTAHYDRATE
| Melting point: | 240-250 °C |
| storage temp. | 0-6°C |
| solubility | Aqueous (Slightly, Sonicated), Water (Sparingly, Heated, Sonicated) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Stability: | Hygroscopic |
Safety information for FOLINIC ACID CALCIUM SALT PENTAHYDRATE
Computed Descriptors for FOLINIC ACID CALCIUM SALT PENTAHYDRATE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium 3-Bromopyrazole (3aR,4R,5R,6aS)-hexahydro-5-Triethyl silyloxy-4-((E)-3-oxo-5-phenylpent-1- enyl)cyclopenta[b]furan-2-one. 1-Chlorocarbonyl-4-piperidinopiperidine 1-Bromo-4-phenyl-2-Butanone 4-Amino-2-fluoro-N-methylbenzamide 1,1'-Carbonyldiimidazole SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTIONRelated products of tetrahydrofuran
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