Fmoc-Pro-OH
Synonym(s):N-(9-Fluorenylmethoxycarbonyl)-L -proline;Fmoc-L -proline;Fmoc-Pro-OH;N-α-Fmoc-L-proline
- CAS NO.:71989-31-6
- Empirical Formula: C20H19NO4
- Molecular Weight: 337.37
- MDL number: MFCD00065670
- EINECS: 276-259-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 20:41:25
What is Fmoc-Pro-OH?
Description
Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.
Chemical properties
white to light yellow crystal powder.
The Uses of Fmoc-Pro-OH
L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
Preparation
To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).
General Description
The product number for this product was previously 04-12-1031.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
Properties of Fmoc-Pro-OH
Melting point: | 117-118 °C(lit.) |
Boiling point: | 473.68°C (rough estimate) |
alpha | -32 º (c=1,DMF) |
Density | 1.2486 (rough estimate) |
refractive index | -32.5 ° (C=1, DMF) |
storage temp. | Store below +30°C. |
solubility | Soluble in methanol. (almost transparency.) |
form | Solid |
pka | 3.95±0.20(Predicted) |
color | White to Off-White |
optical activity | [α]20/D 32±1°, c = 1% in DMF |
Concentration | 0.1 mCi/ml |
Solvent | Ethanol |
Specific Activity | 50-60 mCi/mmol |
BRN | 3596735 |
CAS DataBase Reference | 71989-31-6(CAS DataBase Reference) |
Safety information for Fmoc-Pro-OH
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fmoc-Pro-OH
Abamectin manufacturer
TYNDAL LABS PVT LTD
TEADUS PHARMA PRIVATE LIMITED
SV CHEM INTERMEDITES PRIVATE LIMITED
JSK Chemicals
Khagga Life Sciences
SIDDHI VINAYAKA SPECHEM PVT LTD
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen 4-Hydroxy Carbazole 4-((2-isopropoxyethoxy)methyl)phenol 2 – Methoxy – 5- Sulfamoyl Benzoic acid Amino Salicylic Acid. U.S.P. 1,2,3,4-Tetrahydrocarbazol-4-one Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract (S)-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-Yl)Phenyl)Mo Ethyl N-[[2-[[[4-(Aminoiminomethyl)Phenyl]Amino]Methyl] 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Cypermethric Acid Chloride Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
You may like
-
71989-31-6 98%View Details
71989-31-6 -
FMOC-L-Proline 71989-31-6 98%View Details
71989-31-6 -
Fmoc-Pro-OH 97% CAS 71989-31-6View Details
71989-31-6 -
Fmoc-L-proline CAS 71989-31-6View Details
71989-31-6 -
Fmoc-L-proline, puriss CAS 71989-31-6View Details
71989-31-6 -
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline CAS 71989-31-6View Details
71989-31-6 -
Fmoc-Pro-OH CAS 71989-31-6View Details
71989-31-6 -
Fmoc-Pro-OH CAS 71989-31-6View Details
71989-31-6