Fmoc-Leu-OH

Description

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Chemical properties

white to light yellow crystal powde

The Uses of Fmoc-Leu-OH

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

What are the applications of Application

Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.

What are the applications of Application

NPC 15199 is an N-protected leucine analog

Preparation

Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.

Biological Activity

Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.