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HomeProduct name listFmoc-Gly-OH

Fmoc-Gly-OH

Synonym(s):FMOC-Glycine;Fmoc-Gly-OH;N-α-Fmoc-glycine

  • CAS NO.:29022-11-5
  • Empirical Formula: C17H15NO4
  • Molecular Weight: 297.31
  • MDL number: MFCD00037140
  • EINECS: 249-373-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-02 17:19:06
Fmoc-Gly-OH Structural

What is Fmoc-Gly-OH?

Chemical properties

white to light yellow crystal powde

The Uses of Fmoc-Gly-OH

N-Fmoc-glycine is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.

What are the applications of Application

Fmoc-Gly-OH is an Fmoc protected glycine derivative

Preparation

Glycine (Gly) (0.5 g, 6.66 mmol) was dissolved in 10% NaCO3 (14 ml) under stirring in a 50-ml flask. To the resulting solution, which had been put into an ice bath, 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) (1.72 g, 6.66 mmol) in dioxane (12 ml) was gradually added. The reaction mixture was stirred at room temperature for 4 hours. Then added water (150 ml) to the mixture. The aqueous phase layer was separated from the reaction mixture and stripped with ether three times (75 ml×3). The stripped aqueous layer was acidified with 2N HCl aqueous solution to a pH=2, followed by extraction with ethyl acetate three times (75 ml×3). The organic phase layer was recovered and concentrated to obtain crude product of 1.70 g. The crude product was recrystallized in a mixed solvent of ethyl acetate hexane=1:2 (30 ml), and white solid denoted as Fmoc-Gly-OH was obtained after filtration at a reduced pressure.
Fmoc-Gly-OH

General Description

The product number for this product was previously 04-12-1001.

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Properties of Fmoc-Gly-OH

Melting point: 174-175 °C(lit.)
Boiling point: 438.82°C (rough estimate)
Density  1.1671 (rough estimate)
refractive index  1.4500 (estimate)
storage temp.  2-8°C
solubility  almost transparency in Methanol
pka 3.89±0.10(Predicted)
form  Powder
color  White
BRN  2163967
InChI InChI=1S/C17H15NO4/c19-16(20)9-18-17(21)22-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9-10H2,(H,18,21)(H,19,20)
CAS DataBase Reference 29022-11-5(CAS DataBase Reference)

Safety information for Fmoc-Gly-OH

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Fmoc-Gly-OH

InChIKey NDKDFTQNXLHCGO-UHFFFAOYSA-N
SMILES C(O)(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

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