Fmoc-L-glutamic acid 5-tert-butyl ester
Synonym(s):Fmoc-L -glutamic acid 5-tert-butyl ester;Fmoc-Glu(OtBu)-OH;N-α-Fmoc-L-glutamic acid γ-t.-butyl ester
- CAS NO.：71989-18-9
- Empirical Formula: C24H27NO6
- Molecular Weight: 425.47
- MDL number: MFCD00037135
- EINECS: 276-253-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-11 15:28:25
What is Fmoc-L-glutamic acid 5-tert-butyl ester?
Description
Fmoc-L-glutamic acid 5-tert-butyl ester is a Fmoc derivative with an N-substituted tert-butyl ester molecule. It is white or gray-white solid crystals at room temperature and pressure, poor solubility in water and insoluble in petroleum ether, but soluble in ethyl acetate, acetic acid and N,N-dimethylformamide.
Chemical properties
White powder
The Uses of Fmoc-L-glutamic acid 5-tert-butyl ester
Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:
- Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
- Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.
It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .
General Description
The product number for this product was previously 04-12-1020.
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Properties of Fmoc-L-glutamic acid 5-tert-butyl ester
| Melting point: | 83-90 °C |
| Boiling point: | 633.5±55.0 °C(Predicted) |
| alpha | -4.5 º (c=1, 80% acetic acid) |
| Density | 1.232±0.06 g/cm3(Predicted) |
| refractive index | -4 ° (C=1, 80% AcOH) |
| storage temp. | Store below +30°C. |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 3.70±0.10(Predicted) |
| color | White to Almost white |
| optical activity | [α]20/D 5.0±2.0°, c = 1% in acetic acid: water (4:1) |
| BRN | 3636375 |
| CAS DataBase Reference | 71989-18-9(CAS DataBase Reference) |
Safety information for Fmoc-L-glutamic acid 5-tert-butyl ester
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for Fmoc-L-glutamic acid 5-tert-butyl ester
| InChIKey | OTKXCALUHMPIGM-FQEVSTJZSA-N |
| SMILES | C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
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product: 71989-18-9 N-Fmoc-L-glutamic acid 5-tert-butyl 99%
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