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HomeProduct name listFlorantyrone

Florantyrone

  • CAS NO.:519-95-9
  • Empirical Formula: C20H14O3
  • Molecular Weight: 302.32
  • MDL number: MFCD00867164
  • EINECS: 208-279-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:39
Florantyrone Structural

What is Florantyrone?

Originator

Zanchol,Searle,US,1957

Definition

ChEBI: Florantyrone is a butanone.

Manufacturing Process

50 g of fluoranthene and 26 g of succinic anhydride in 500 cc of nitrobenzene were treated at 0°C to 5°C with 75 g of anhydrous aluminum chloride. The temperature was held at 0°C for 4 hours and then allowed gradually to come to room temperature. The reaction mixture was allowed to stand for 16 hours. The reaction mixture was then worked up. In so doing, the reaction mixture was decomposed with dilute HCl, the nitrobenzene was removed by steam distillation and the residue after filtration was dissolved in hot sodium carbonate solution and filtered free of a small amount of nonacidic material. Precipitation from solution with HCl gave a light yellow product which crystallized from a 50-50 mixture of dioxane alcohol as fine platelets which melted at 192°C to 194°C and showed a neutral equivalent of 308 which corresponds closely to the theoretical value of 302 for β-fluoranthoylpropionic acid.
25 g of the crude acid was dissolved in 100 cc of water containing 13 g of sodium carbonate. On cooling a thick syrup was obtained. On dilution to 1 liter precipitation started and after standing 16 hours, the solid which separated was filtered (filtrate treated as below), suspended in water, acidified with HCl and filtered. Crystallization from alcohol gave a light yellow material melting at 199°C to 200°C and having a neutral equivalent of 303.
The filtrate mentioned above, upon acidification thereof with HCl gave a darker acid which melted over a wide range, but had a neutral equivalent which also corresponds to that of β-fluoranthoylpropionic acid.

Therapeutic Function

Hydrocholeretic

Properties of Florantyrone

Melting point: 184-187 °C(lit.)
Boiling point: 574.2±33.0 °C(Predicted)
Density  1.367±0.06 g/cm3(Predicted)
CAS DataBase Reference 519-95-9(CAS DataBase Reference)

Safety information for Florantyrone

Computed Descriptors for Florantyrone

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