FLLL31
Synonym(s):(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;Tetramethylcurcumin
- CAS NO.：52328-97-9
- Empirical Formula: C25H28O6
- Molecular Weight: 424.49
- MDL number: MFCD19443859
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
What is FLLL31?
Biological Activity
Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.
in vitro
Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.
Properties of FLLL31
| Boiling point: | 594.5±50.0 °C(Predicted) |
| Density | 1.140±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | yellow |
Safety information for FLLL31
| Signal word | Warning |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for FLLL31
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Rimegepant Impurity 3 Fosfomycin EP impurity D Ivermectin EP Impurity B Tubulysin F (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin I Potassium HMDS (1.0 M in THF) 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 4-(Azidomethyl)-3-chloropyridine 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Diethyl 2,5-di(furan-2-yl)terephthalate 1-(4-Fluorophenyl)piperidin-2-one 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione tert-butyl2-amino-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate 5-Bromo-4,6-difluoro-2,3-dihydro-1h-indole 3-HYDROXY-8-FLUORONAPHTHALENE-1-BORONIC ACID PINACOL ESTERRelated products of tetrahydrofuran
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