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HomeProduct name listDEMETHOXYCURCUMIN

DEMETHOXYCURCUMIN

Synonym(s):(E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione;Curcumin II;Desmethoxycurcumin;Monodemethoxycurcumin

DEMETHOXYCURCUMIN Structural

What is DEMETHOXYCURCUMIN?

The Uses of DEMETHOXYCURCUMIN

Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.

The Uses of DEMETHOXYCURCUMIN

The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.

What are the applications of Application

Demethoxy Curcumin is a demethoxy derivative of Curcumin

Definition

ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.

Properties of DEMETHOXYCURCUMIN

Melting point: 166~170℃
Boiling point: 571.4±50.0 °C(Predicted)
Density  1.282±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ≥10mg/mL
form  powder
pka 8.31±0.46(Predicted)
color  orange

Safety information for DEMETHOXYCURCUMIN

Signal word Warning
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for DEMETHOXYCURCUMIN

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