DEMETHOXYCURCUMIN
Synonym(s):(E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione;Curcumin II;Desmethoxycurcumin;Monodemethoxycurcumin
- CAS NO.:22608-11-3
- Empirical Formula: C20H18O5
- Molecular Weight: 338.35
- MDL number: MFCD03427310
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is DEMETHOXYCURCUMIN?
The Uses of DEMETHOXYCURCUMIN
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.
The Uses of DEMETHOXYCURCUMIN
The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.
What are the applications of Application
Demethoxy Curcumin is a demethoxy derivative of Curcumin
Definition
ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.
Properties of DEMETHOXYCURCUMIN
Melting point: | 166~170℃ |
Boiling point: | 571.4±50.0 °C(Predicted) |
Density | 1.282±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
pka | 8.31±0.46(Predicted) |
color | orange |
Safety information for DEMETHOXYCURCUMIN
Signal word | Warning |
Pictogram(s) |
Environment GHS09 |
GHS Hazard Statements |
H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for DEMETHOXYCURCUMIN
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