FH 535
Synonym(s):β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem;N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide, Wnt Pathway Inhibitor IX
- CAS NO.:108409-83-2
- Empirical Formula: C13H10Cl2N2O4S
- Molecular Weight: 361.2
- MDL number: MFCD01212888
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is FH 535?
Description
FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4
Chemical properties
Dark Yellow Solid
The Uses of FH 535
Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.
The Uses of FH 535
A cell-permeable compound that inhibits Wnt/β-catenin and PPAR
What are the applications of Application
β-Catenin/Tcf Inhibitor, FH535 is a cell-permeable compound that inhibits Wnt/β-catenin and PPAR
Definition
ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide.
Biochem/physiol Actions
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
storage
+4°C
References
1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521 2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418 3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187 4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380 5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880
Properties of FH 535
Melting point: | 141-142℃ |
Boiling point: | 526.3±60.0 °C(Predicted) |
Density | 1.566±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: soluble20mg/mL |
form | Yellow solid |
pka | 5.83±0.10(Predicted) |
color | Tan |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
Safety information for FH 535
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for FH 535
InChIKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
New Products
6-Bromo 2-Iodo Indole Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin G Tubulysin D Tubulysin I Tubulysin A (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(4-Bromopyridin-2-yl)acetonitrile 2-Chloro-3-(chloromethyl)pyridine 4-(Azidomethyl)-3-chloropyridine Methyl 4-amino-3-(dihexylamino)benzoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione Zanubrutinib 3-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylpropanamide 6-bromo-4-methyl-2-propyl-1H-1,3-benzodiazole 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidineRelated products of tetrahydrofuran
You may like
-
β-Catenin/Tcf Inhibitor, FH535 CAS 108409-83-2View Details
108409-83-2 -
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
1262243-12-8View Details
1262243-12-8 -
65195-56-4View Details
65195-56-4 -
Rimegepant Impurity 3View Details
-
Sidchem 730View Details
-
Sidchem BT 20View Details
-
1572177-89-9View Details
1572177-89-9