FGF-401
- CAS NO.：1708971-55-4
- Empirical Formula: C25H30N8O4
- Molecular Weight: 506.56
- MDL number: MFCD31381923
- Update Date: 2024-11-19 23:02:33
What is FGF-401?
Description
FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.
Properties of FGF-401
| Boiling point: | 852.1±65.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:5.4(Max Conc. mg/mL);10.66(Max Conc. mM) Chloroform:30.0(Max Conc. mg/mL);59.22(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.40±0.20(Predicted) |
| color | White to off-white |
Safety information for FGF-401
Computed Descriptors for FGF-401
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