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HomeProduct name listFENOVERINE

FENOVERINE

  • CAS NO.:37561-27-6
  • Empirical Formula: C26H25N3O3S
  • Molecular Weight: 459.56
  • MDL number: MFCD00865242
  • EINECS: 253-552-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
FENOVERINE Structural

What is FENOVERINE?

Originator

Spasmopriv,Paillusseau

The Uses of FENOVERINE

Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs.

Definition

ChEBI: Fenoverine is a member of phenothiazines.

Manufacturing Process

To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene was added a little quantity of bromine and then were added dropwise 136 g (0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours. After cooling the mixture was concentrated in vacuo. Product was dissolved at reflux in ethanol absolute and filtered. At room temperature was crystallized chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05 mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of dry toluene was refluxed for 3 hours. Then the solution was cooled and filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1- piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P. 141-142°C; yield 67%.

Therapeutic Function

Spasmolytic

Properties of FENOVERINE

Melting point: 141-142°
Boiling point: 671.8±55.0 °C(Predicted)
Density  1.343±0.06 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 6.47±0.10(Predicted)
form  Solid
color  Pale Beige to Beige
Stability: Hygroscopic

Safety information for FENOVERINE

Computed Descriptors for FENOVERINE

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