FENOVERINE

CAS NO.：37561-27-6
Empirical Formula: C26H25N3O3S
Molecular Weight: 459.56
MDL number: MFCD00865242
EINECS: 253-552-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is FENOVERINE?

Originator

Spasmopriv,Paillusseau

The Uses of FENOVERINE

Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs.

Definition

ChEBI: Fenoverine is a member of phenothiazines.

Manufacturing Process

To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene was added a little quantity of bromine and then were added dropwise 136 g (0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours. After cooling the mixture was concentrated in vacuo. Product was dissolved at reflux in ethanol absolute and filtered. At room temperature was crystallized chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05 mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of dry toluene was refluxed for 3 hours. Then the solution was cooled and filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1- piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P. 141-142°C; yield 67%.

Therapeutic Function

Spasmolytic

Properties of FENOVERINE

Melting point:	141-142°
Boiling point:	671.8±55.0 °C(Predicted)
Density	1.343±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	6.47±0.10(Predicted)
form	Solid
color	Pale Beige to Beige
Stability:	Hygroscopic