ETRIMFOS
Synonym(s):O-(6-Ethoxy-2-ethyl-4-pyrimidinyl) O,O-dimethyl thiophosphate
- CAS NO.:38260-54-7
- Empirical Formula: C10H17N2O4PS
- Molecular Weight: 292.29
- MDL number: MFCD00055516
- EINECS: 253-855-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:38
What is ETRIMFOS?
Description
Etrimfos is a colorless liquid, mp ?3.35 ?C, vp 6.5 mPa (20 ?C). Solubility in water is 40 mg/L (23–24 ?C). It is miscible with most organic solvents. Log Kow > 3.3. Neat etrimfos is unstable and degrades ca. 40% in 28 d at 50 ?C, but the dilute solutions in nonpolar solvents and its formulations are stable (about 5% loss in 1 y at ca. 20 ?C). It is hydrolyzed in aqueous media; DT50 (25 ?C) at pH 3, 6, and 9 are 0.4, 16, and 14 d, respectively.
The Uses of ETRIMFOS
Etrimfos is used to control chewing insects in top fruit, vines, olives and a number of other crops. It is also used to control stem borers in rice and insect and acarid pests of stored products.
The Uses of ETRIMFOS
Satisfar is a pesticide sprayed on plants and vegetables as insecticide to fend off pests.
The Uses of ETRIMFOS
Agricultural insecticide.
What are the applications of Application
Etrimfos is a useful pesticide/insecticide
Definition
ChEBI: Etrimfos is an organic thiophosphate.
Hazard
Toxic.
Metabolic pathway
Etrimfos is principally degraded in soil and plants via dearylation of etrimfos itself or by hydrolysis of etrimfos oxon to the pyrimidinol (6-ethoxy-4-hydroxy-2-ethylpyrimidine), further metabolism of which involves de-ethylation to a dihydroxypyrimidine (2-ethyl-4,6-dihydroxypyrimidine). In mammals both hydrolysis and demethylation to desmethyl etrimfos are involved in detoxification. Additionally, the ethyl and ethoxy groups of the pyrimidinol hydrolysis product may be hydroxylated and conjugated. Etrimfos oxon is metabolically highly unstable and is often not detected.
Degradation
Etrimfos is unstable when pure but dilute solutions in non-polar solvents and formulations are stable. Half-lives in water at pH 3,6 and 9 were 0.4, 16 and 14 days, respectively. Etrimfos is stable to light (PM).
Toxicity evaluation
The acute oral LD50 for rats is 1,600–1,800 mg/kg. Inhalation LC50 (1 h) for rats is >200 mg/L air. NOEL (2 yr) for rats is 6 mg/kg diet (0.3 mg/kg/d). ADI is 3 μg/kg b.w. The principal degradation pathway in mammals, plants, and soils is pyrimidinyl ester bond cleavage: the major metabolites are 6-ethoxy-4-hydroxy- 2-ethylpyrimidine and its further transformed products. Degradation in mammals involves demethylation to desmethyl etrimfos. The DT50 in soils at pH 6.8 was 3–10 d.
Properties of ETRIMFOS
Melting point: | -3.35℃ |
Boiling point: | approximate 77℃ |
Density | 1.195 g/cm3 (20℃) |
vapor pressure | 6.5 x 10-3 Pa (24 °C) |
refractive index | nD20 1.5068 |
Flash point: | >100 °C |
storage temp. | APPROX 4°C
|
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
Water Solubility | 40 mg l-1 (23-24 °C) |
form | liquid |
pka | -0.67±0.32(Predicted) |
color | Colourless |
Merck | 13,3923 |
BRN | 7136389 |
CAS DataBase Reference | 38260-54-7 |
EPA Substance Registry System | Etrimfos (38260-54-7) |
Safety information for ETRIMFOS
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for ETRIMFOS
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