Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listETOPERIDONE

ETOPERIDONE

ETOPERIDONE Structural

What is ETOPERIDONE?

Originator

Etoperidone,ZYF Pharm

The Uses of ETOPERIDONE

Antidepressant.

Definition

ChEBI: Etoperidone is a member of piperazines.

Manufacturing Process

(a). 3,4-Diethyl-δ2-1,2,4-triazolin-5-one (62 g) is dissolved in anhydrous dioxane (about 500 ml) and NaH (21 g) in a 50 percent oily suspension is added. The solution is heated for 30 min under reflux and NmetachlorophenyI- N'-(3-chloro-n-propyl)piperazine (119 g) is added under stirring. The solution is heated for 20 hours under reflux. The solvent is then eliminated under reduced pressure and the residue is treated with 2 N HCl. The solution is washed with ether so as to eliminate the oil present in the hydride solution, and made alkaline with 50% K2CO3. It is extracted with ether and dried, the solvent is eliminated and the residue is distilled under reduced pressure. 115 g of 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)- 4,5-diethyl-2,4-dihydro-1,2,4-triazol-3-one are obtained. B.P. 230°C/0.5 mm.
2-(3-(4-(3-Chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-1,2,4- triazol-3-one hydrochloride was prepared by standard procedures, melting point 197-198°C (recrystallization from isopropanol).
(b). 3,4-Diethyl-δ2-1,2,4-triazolin-5-one (1 g) and 3-bromo-1-chloropropane (6.6 g) are added to a solution of Na (0.98 g) in methanol (20 ml). The solution is refluxed until the pH becomes neutral, poured into water, extracted with ether. The solvent is eliminated and the residual oil is distilled. 1-(3- Chloropropyl)-3,4-diethyl-δ2-1,2,4-triazolin-5-one boils at 121°C/0.05 mm.
1-(3-Chloropropyl)-3,4-diethyl-δ2-1,2,4-triazolin-5-one (1.0 g), NmetachlorophenyIpiperazine (0.9 g) and triethylamine (0.46 g) in toluene (25 ml) are refluxed for 12 hours. The solution is treated with 5 N NaOH, extracted with ether and steam-distilled. The residue is extracted with ether and the ethereal solution is treated with ethereal HCl. 2-(3-(4-(3- Chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-1,2,4-triazol-3- one hydrochloride has melting point 197-198°C (recrystallization from isopropanol).

brand name

Etonin (Ortho-McNeil).

Therapeutic Function

Antidepressant, Anxiolytic

Properties of ETOPERIDONE

Boiling point: bp0.5 230°

Safety information for ETOPERIDONE

Computed Descriptors for ETOPERIDONE

Related products of tetrahydrofuran

You may like

  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 88491-46-7 98%
    88491-46-7 98%
    88491-46-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.