Ethyl 7-chloro-2-oxoheptanoate

CAS NO.：78834-75-0
Empirical Formula: C9H15ClO3
Molecular Weight: 206.67
MDL number: MFCD07698675
EINECS: 278-992-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

What is Ethyl 7-chloro-2-oxoheptanoate?

Chemical properties

Colorless to Light orange to Yellow clear liquid.

The Uses of Ethyl 7-chloro-2-oxoheptanoate

Ethyl 7-Chloro-2-oxoheptanoate is a reagent used in the synthesis of selective BCL-XL inhibitor A1155463 used in the treatment of cancer.

The Uses of Ethyl 7-chloro-2-oxoheptanoate

Ethyl 7-chloro-2-oxoheptanoate is a product of the Grignard reaction that can be used to synthesize organic compounds. It has been used in the preparation of pharmaceuticals such as cilastatin, which is used to inhibit cytochrome P450 enzymes in order to prolong the effectiveness of other drugs. This reagent also reacts with hydrochloric acid to form ethyl chloride and heptanoic acid, which can be used for chlorination reactions.

Preparation

Ethyl 7-chloro-2-oxoheptanoate is an organochlorine compound that is obtained by reacting ethyl chloride with magnesium in the presence of benzene and cilastatin as a catalyst.

Properties of Ethyl 7-chloro-2-oxoheptanoate

Boiling point:	281.2±23.0 °C(Predicted)
Density	1.093±0.06 g/cm3(Predicted)
refractive index	1.4510 to 1.4560
storage temp.	Inert atmosphere,2-8°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Liquid
color	Clear Yellow
CAS DataBase Reference	78834-75-0(CAS DataBase Reference)