Ethyl 3-hydroxybutyrate
Synonym(s):grape butyrate
- CAS NO.:5405-41-4
- Empirical Formula: C6H12O3
- Molecular Weight: 132.16
- MDL number: MFCD00004545
- EINECS: 226-456-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 21:39:59
What is Ethyl 3-hydroxybutyrate?
Chemical properties
Ethyl-3-hydroxybutyrate is a clear colorless viscous liquid and has a fresh, fruity, grape odor. It is one of the main aroma components of wine. It occurs naturally in fruits such as pineapple, tamarillo fruit, caja fruit and naranjilla fruit.
Occurrence
Reported found in passion fruit, rum, sherry, wine, orange juice, guava, pineapple, tea, mango, wood apple, mountain papaya, naranjilla fruit, quince and hog plum (Spondias mombins L.)
The Uses of Ethyl 3-hydroxybutyrate
Ethyl 3-hydroxybutyrate is a fragrance found in wine and Tribolium castaneum. It is a reagent used to synthesize α-azido carboxylic acids. It is also used in Palladium mediated spiroketal synthesis.
Definition
ChEBI: Ethyl 3-hydroxybutyrate is the fatty acid ethyl ester of 3-hydroxybutyric acid. It has a role as a metabolite. It derives from a 3-hydroxybutyric acid.
Preparation
Ethyl 3-hydroxybutyrate is synthesized by catalytic hydrogenation of ethyl acetoacetate.
Taste threshold values
Taste characteristics at 30 ppm: green, fruity and winy.
Synthesis Reference(s)
The Journal of Organic Chemistry, 35, p. 3966, 1970 DOI: 10.1021/jo00836a087
Tetrahedron Letters, 31, p. 1615, 1990 DOI: 10.1016/0040-4039(90)80031-G
General Description
Ethyl 3-hydroxybutyrate is a clear colorless liquid. (NTP, 1992)
Air & Water Reactions
Water soluble.
Reactivity Profile
Ethyl 3-hydroxybutyrate is incompatible with strong oxidizing agents and strong bases.
Fire Hazard
Ethyl 3-hydroxybutyrate is combustible.
Properties of Ethyl 3-hydroxybutyrate
Boiling point: | 170 °C (lit.) |
Density | 1.017 g/mL at 25 °C (lit.) |
refractive index | n |
FEMA | 3428 | ETHYL 3-HYDROXYBUTYRATE |
Flash point: | 148 °F |
storage temp. | Sealed in dry,2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Liquid |
pka | 14.45±0.20(Predicted) |
color | Clear colorless |
Odor | at 100.00 %. fruity green grape tropical apple skin |
JECFA Number | 594 |
BRN | 1446190 |
CAS DataBase Reference | 5405-41-4(CAS DataBase Reference) |
NIST Chemistry Reference | Butanoic acid, 3-hydroxy-, ethyl ester(5405-41-4) |
EPA Substance Registry System | Ethyl 3-hydroxybutyrate (5405-41-4) |
Safety information for Ethyl 3-hydroxybutyrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for Ethyl 3-hydroxybutyrate
InChIKey | OMSUIQOIVADKIM-UHFFFAOYSA-N |
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