Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
- CAS NO.:473927-63-8
- Empirical Formula: C11H13ClN2O3
- Molecular Weight: 256.69
- EINECS: 696-101-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-15 13:21:15
What is Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate?
The Uses of Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes.
Synthesis
Preparation of ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate To p-anisidine (16 g, 0.129 mol) in conc. HCL (40 mL), 100 mL) H2O, cooled to -5?? C. and sodium nitrite (9.4 g, 0.136 mol) in H2O (60 mL) was added. The reaction mixture was stirred at -5?? C. for 20 min and a mixture of ethylchloroacetoacetate (22 g, 0.133 mol), ethanol (100 mL), sodiumacetate (32 g, 0.389 mmol), and H2O (400 mL) was added. The reaction was allowed to warm up to room temperature and stirred for 2h. The product precipitated as a black solid. It was filtered and dried (30 g). 1H-NMR (CDCl3) |? 8.28 (s, 1H), 7.18 (d, 2H), 6.90 (d, 2H), 4.41 (q, 2H), 3.80 (s, 3H), 1.42 (t, 3H) ppm.
Properties of Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
Boiling point: | 349.0±44.0 °C(Predicted) |
Density | 1.23 |
vapor pressure | 0.008Pa at 25℃ |
pka | 11.63±0.10(Predicted) |
InChI | InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3/b14-10- |
Safety information for Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation H341:Germ cell mutagenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
InChIKey | ATNPZEGMKLGIFA-UVTDQMKNSA-N |
SMILES | C(OCC)(=O)/C(/Cl)=N/NC1=CC=C(OC)C=C1 |
Abamectin manufacturer
LAIRUS PHARMA PVTLTD
Nandana Laboratories Pvt. Ltd.(NLPL)
ARRKEM LIFE SCIENCES PRIVATE LIMITED
Arnavi Laboratory
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