Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

CAS NO.：887267-53-0
Empirical Formula: C11H10F2O3
Molecular Weight: 228.19
MDL number: MFCD07783808
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-20 10:42:06

What is Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate?

The Uses of Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate is commonly utilized in organic synthesis as C-nucleophiles. One specific example is its reaction with the N-terminal electrophile CF3CHN2, resulting in the formation of CF3-heterocycles, namely ethyl 6-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydrocinnoline-3-carboxylate[1].
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

References

[1] Arkhipov A, et al. Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N?Atom. Organic Letters, 2016; 18: 3406–3409.

Properties of Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

Boiling point:	275.7±25.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
pka	10.28±0.50(Predicted)

Safety information for Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.