Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- CAS NO.：887267-53-0
- Empirical Formula: C11H10F2O3
- Molecular Weight: 228.19
- MDL number: MFCD07783808
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-20 10:42:06
What is Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate?
The Uses of Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate is commonly utilized in organic synthesis as C-nucleophiles. One specific example is its reaction with the N-terminal electrophile CF3CHN2, resulting in the formation of CF3-heterocycles, namely ethyl 6-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydrocinnoline-3-carboxylate[1].
References
[1] Arkhipov A, et al. Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N?Atom. Organic Letters, 2016; 18: 3406–3409.
Properties of Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
| Boiling point: | 275.7±25.0 °C(Predicted) |
| Density | 1.251±0.06 g/cm3(Predicted) |
| pka | 10.28±0.50(Predicted) |
Safety information for Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
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