Ethyl 2-chloronicotinate

Synonym(s):Ethyl 2-chloronicotinate;Ethyl 2-chloropyridine-3-carboxylate

CAS NO.：1452-94-4
Empirical Formula: C8H8ClNO2
Molecular Weight: 185.61
MDL number: MFCD00674129
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-25 20:04:51

What is Ethyl 2-chloronicotinate?

Chemical properties

Light yellow liquid

The Uses of Ethyl 2-chloronicotinate

Ethyl 2-chloronicotinate,is used as a pharmaceutical intermediate.

Synthesis Reference(s)

Tetrahedron, 51, p. 13177, 1995 DOI: 10.1016/0040-4020(95)00788-A

Synthesis

2-Chloropyridine-3-carboxylic acid (7.9 g) and thionyl chloride (45 ml) were heated for 3 hours in benzene (65 ml) under reflux. The reaction mixture was concentrated to leave an oil, which was added dropwise to ethanol (40 ml). The mixture was heated for a further one hour under reflux. The solvent was distilled, and the residue was dissolved in toluene. The solution was dried over anhydrous magnesium sulfate. The solvent was distilled to leave Ethyl 2-chloronicotinate (8.4 g, 90%) as a pale yellow oil.

Properties of Ethyl 2-chloronicotinate

Melting point:	68 C
Boiling point:	78°C (0.1 mmHg)
Density	1.2445 g/cm3(Temp: 25 °C)
refractive index	1.5210-1.5250
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-1.32±0.10(Predicted)
form	neat
form	Liquid
color	Colorless to Light yellow to Light orange
InChI	InChI=1S/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3
CAS DataBase Reference	1452-94-4(CAS DataBase Reference)

Safety information for Ethyl 2-chloronicotinate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.