ETHYL 1,3-DITHIOLANE-2-CARBOXYLATE
Synonym(s):Glyoxylic acid ethyl ester ethylene mercaptal
- CAS NO.：20461-99-8
- Empirical Formula: C6H10O2S2
- Molecular Weight: 178.27
- MDL number: MFCD00005411
- EINECS: 243-837-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:36
What is ETHYL 1,3-DITHIOLANE-2-CARBOXYLATE?
Chemical properties
clear light yellow liquid
General Description
Ethyl 1,3-dithiolane-2-carboxylate is an α-keto acid equivalent. It participates in the conjugate additions to enones. It is a bulky equivalent of acetate undergoing syn-selective aldol reactions. Anion derived from ethyl 1,3-dithiolane-2-carboxylate participates as nucleophile during the total synthesis of the corynanthe alkaloid dihydrocorynantheol and the formal syntheses of the indole alkaloids tacamonine, rhynchophylline and hirsutine. It also participates in the conjugate addition of enolates to phenylglycinol-derived α,β-unsaturated δ-lactams.
Purification Methods
Dissolve the ester in CHCl3, wash it with aqueous K2CO3, twice with H2O, dry it over MgSO4, filter, evaporate and distil the residue in vacuo. [Hermann et al Tetrahedron Lett 2599 1973, Corey & Erickson J Org Chem 36 3553 1971]. [Beilstein 19/7 V 225.]
Properties of ETHYL 1,3-DITHIOLANE-2-CARBOXYLATE
| Boiling point: | 85 °C/0.1 mmHg (lit.) |
| Density | 1.249 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear light yellow |
| Specific Gravity | 1.249 |
| BRN | 118157 |
| CAS DataBase Reference | 20461-99-8(CAS DataBase Reference) |
Safety information for ETHYL 1,3-DITHIOLANE-2-CARBOXYLATE
Computed Descriptors for ETHYL 1,3-DITHIOLANE-2-CARBOXYLATE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium 3-Bromopyrazole (3aR,4R,5R,6aS)-hexahydro-5-Triethyl silyloxy-4-((E)-3-oxo-5-phenylpent-1- enyl)cyclopenta[b]furan-2-one. 1-Chlorocarbonyl-4-piperidinopiperidine 1-Bromo-4-phenyl-2-Butanone 4-Amino-2-fluoro-N-methylbenzamide 1,1'-Carbonyldiimidazole SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTIONRelated products of tetrahydrofuran
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