Ethyl 1-methylnipecotate

Synonym(s):1-Methyl-nipecotic acid ethyl ester;Ethyl 1-methylnipecotate;NSC 64739

CAS NO.：5166-67-6
Empirical Formula: C9H17NO2
Molecular Weight: 171.24
MDL number: MFCD00006496
EINECS: 225-951-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-20 19:26:33

What is Ethyl 1-methylnipecotate?

Chemical properties

Clear colorless to pale yellow liquid

The Uses of Ethyl 1-methylnipecotate

Reactant for:
N-demethylation of tertiary amines
Reverse cope elimination reactions
Regioselective oxidation
Synthesis of chelating agents
Sequential Michael-Michael-Dieckmann cyclizations

General Description

Enantiomeric discrimination has been investigated in ¹H and ¹³C NMR spectra of ethyl 1-methyl-3-piperidinecarboxylate in the presence of (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.

Properties of Ethyl 1-methylnipecotate

Boiling point:	88-89 °C/11 mmHg (lit.)
Density	0.954 g/mL at 25 °C (lit.)
refractive index	n20/D 1.451(lit.)
Flash point:	155 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
pka	8.56±0.10(Predicted)
color	Colorless to Almost colorless
BRN	123259
CAS DataBase Reference	5166-67-6(CAS DataBase Reference)
NIST Chemistry Reference	Ethyl 1-methylnipecotate(5166-67-6)

Safety information for Ethyl 1-methylnipecotate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.