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HomeProduct name listEthopabate

Ethopabate

Synonym(s):Ethopabate;Ethyl pabate;Methyl 4-acetamido-2-ethoxybenzoate

  • CAS NO.:59-06-3
  • Empirical Formula: C12H15NO4
  • Molecular Weight: 237.25
  • MDL number: MFCD00075809
  • EINECS: 200-414-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
Ethopabate Structural

What is Ethopabate?

Description

Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.

Chemical properties

White to Off-White Solid

The Uses of Ethopabate

A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.

The Uses of Ethopabate

antidepressant

Definition

ChEBI: Ethopabate is an amidobenzoic acid.

Clinical Use

Ethopabate is only a narrow anticoccidial spectrum drug against Eimeria acervulina. It has no or only slight activity against E. maxima, E. necatrix, E. tenella or E. brunetti. Today, ethopabate is applied only in combination with amprolium and sulfonamide.

Molecular Interactions

Ethopabate is a 2-substituted PABA derivative (=4-acetamido-2-ethoxybenzoic acid methylester) and functions as a prodrug. Its activity becomes potentiated by pyrimethamine and antagonised by the simultaneous administration of PABA. Thus, the mode of action of ethopabate is similar to that of sulfonamides or sulfones.

Properties of Ethopabate

Melting point: 148-151 °C
Boiling point: 426.1±35.0 °C(Predicted)
Density  1.180±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO: 50 mg/mL (210.75 mM)
pka 14.12±0.70(Predicted)
form  A solid
color  White to off-white
Merck  13,3781
InChI InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)
CAS DataBase Reference 59-06-3(CAS DataBase Reference)
EPA Substance Registry System Ethopabate (59-06-3)

Safety information for Ethopabate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Ethopabate

InChIKey GOVWOKSKFSBNGD-UHFFFAOYSA-N
SMILES C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC

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