Ethopabate
Synonym(s):Ethopabate;Ethyl pabate;Methyl 4-acetamido-2-ethoxybenzoate
- CAS NO.:59-06-3
- Empirical Formula: C12H15NO4
- Molecular Weight: 237.25
- MDL number: MFCD00075809
- EINECS: 200-414-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Ethopabate?
Description
Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.
Chemical properties
White to Off-White Solid
The Uses of Ethopabate
A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.
The Uses of Ethopabate
antidepressant
Definition
ChEBI: Ethopabate is an amidobenzoic acid.
Clinical Use
Ethopabate is only a narrow anticoccidial spectrum drug against Eimeria acervulina. It has no or only slight activity against E. maxima, E. necatrix, E. tenella or E. brunetti. Today, ethopabate is applied only in combination with amprolium and sulfonamide.
Molecular Interactions
Ethopabate is a 2-substituted PABA derivative (=4-acetamido-2-ethoxybenzoic acid methylester) and functions as a prodrug. Its activity becomes potentiated by pyrimethamine and antagonised by the simultaneous administration of PABA. Thus, the mode of action of ethopabate is similar to that of sulfonamides or sulfones.
Properties of Ethopabate
Melting point: | 148-151 °C |
Boiling point: | 426.1±35.0 °C(Predicted) |
Density | 1.180±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: 50 mg/mL (210.75 mM) |
pka | 14.12±0.70(Predicted) |
form | A solid |
color | White to off-white |
Merck | 13,3781 |
InChI | InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14) |
CAS DataBase Reference | 59-06-3(CAS DataBase Reference) |
EPA Substance Registry System | Ethopabate (59-06-3) |
Safety information for Ethopabate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Ethopabate
InChIKey | GOVWOKSKFSBNGD-UHFFFAOYSA-N |
SMILES | C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC |
Abamectin manufacturer
Meck Pharmaceuticals and Chemicals Pvt. Ltd.
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