ETAZOLATE
Synonym(s):1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;SQ 20009
- CAS NO.：51022-77-6
- Empirical Formula: C14H19N5O2
- Molecular Weight: 289.33
- MDL number: MFCD00600136
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is ETAZOLATE?
Chemical properties
Off-White Solid
The Uses of ETAZOLATE
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
The Uses of ETAZOLATE
PDE inhibitor
The Uses of ETAZOLATE
An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.
Definition
ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).
Properties of ETAZOLATE
| Melting point: | 193-194°C |
| Boiling point: | 427.6±55.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | H2O: >20 mg/mL Solutions should be freshly prepared. |
| form | solid |
| pka | 9.94±0.70(Predicted) |
| color | white |
| CAS DataBase Reference | 51022-77-6 |
Safety information for ETAZOLATE
Computed Descriptors for ETAZOLATE
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin C Tubulysin D Tubulysin H CYCLOBUTYLAMINE HYDROCHLORIDE 2H-Pyran, 4-ethynyltetrahydro- Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- tetrahydro-4-methyl-2H-pyran 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-Aminocyclobutanone hydrochloride 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](https://img.chemicalbook.in/CAS/GIF/952182-02-4.gif)
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