ETAZOLATE
Synonym(s):1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;SQ 20009
- CAS NO.：51022-77-6
- Empirical Formula: C14H19N5O2
- Molecular Weight: 289.33
- MDL number: MFCD00600136
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is ETAZOLATE?
Chemical properties
Off-White Solid
The Uses of ETAZOLATE
PDE inhibitor
The Uses of ETAZOLATE
An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.
The Uses of ETAZOLATE
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
Definition
ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).
Properties of ETAZOLATE
| Melting point: | 193-194°C |
| Boiling point: | 427.6±55.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | H2O: >20 mg/mL Solutions should be freshly prepared. |
| form | solid |
| pka | 9.94±0.70(Predicted) |
| color | white |
| CAS DataBase Reference | 51022-77-6 |
Safety information for ETAZOLATE
Computed Descriptors for ETAZOLATE
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](https://img.chemicalbook.in/CAS/GIF/952182-02-4.gif)
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