Erythromycin stearate

Chemical properties

White Solid

Originator

Erythrocin Stearate,Abbott,US,1952

The Uses of Erythromycin stearate

Semi-synthetic macrolide antibiotic. Antibacterial

The Uses of Erythromycin stearate

oil lubricant, plasticizer, solvent

The Uses of Erythromycin stearate

Macrodiles antibacterial

What are the applications of Application

Erythromycin Stearate is a macrolide, acid labile compound

Definition

ChEBI: Erythromycin stearate is an aminoglycoside.

Manufacturing Process

To a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and 1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete solution is obtained and stirring is then discontinued. The solution is allowed to stand overnight. The solution is diluted to 250 ml by the addition of methylene chloride and washed three times with 100 ml portions of water followed by two washes with 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and filtered, the solvent being removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.

brand name

Bristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).

Therapeutic Function

Antibacterial

General Description

Fluffy colorless powder or fine white powder.

General Description

Erythromycin stearate (Ethril, Wyamycin S, Erypar) is thestearic acid salt of erythromycin. Like erythromycin base,the stearate is acid labile. It is film coated to protect it fromacid degradation in the stomach. In the alkaline pH of theduodenum, the free base is liberated from the stearateand absorbed. Erythromycin stearate is a crystalline powderthat is practically insoluble in water but soluble in alcoholand ether.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A base. Readily forms salts with acids.

Fire Hazard

Flash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.