Erythromycin A Oxime

CAS NO.：111321-02-9
Empirical Formula: C37H68N2O13
Molecular Weight: 748.95
MDL number: MFCD08062410
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is Erythromycin A Oxime?

Description

(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .

Chemical properties

Off-White Solid

The Uses of Erythromycin A Oxime

(9E)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans. It has anti-Helicobacter pylori activity

The Uses of Erythromycin A Oxime

Intermediate of Azithromycin. Antibacterial agent.

The Uses of Erythromycin A Oxime

Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial and potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin).

What are the applications of Application

Erythromycin A oxime is a less acid labile analogue of erythromycin with improved oral absorption

Properties of Erythromycin A Oxime

Melting point:	156-166 °C
Boiling point:	841.0±65.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly,
form	Solid
pka	11.96±0.70(Predicted)
color	White to Off-White