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HomeProduct name listEntecavir Impurity

Entecavir Impurity

  • CAS NO.:1333204-94-6
  • Empirical Formula: C12H15N5O3
  • Molecular Weight: 277.28
  • MDL number: MFCD11100789
  • Update Date: 2023-05-04 17:34:33
Entecavir  Impurity Structural

What is Entecavir Impurity?

The Uses of Entecavir Impurity

(1R,3S,4S)-Entecavir is an impurity of Entecavir (E558900).

Definition

ChEBI: Entecavir (anhydrous) is guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B. It has a role as an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral drug. It is a member of 2-aminopurines, an oxopurine, a primary alcohol and a secondary alcohol.

Properties of Entecavir Impurity

Boiling point: 661.4±65.0 °C(Predicted)
Density  1.81±0.1 g/cm3(Predicted)
pka 14.22±0.60(Predicted)

Safety information for Entecavir Impurity

Computed Descriptors for Entecavir Impurity

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