Endoxifen

CAS NO.：112093-28-4
Empirical Formula: C25H27NO2
Molecular Weight: 373.49
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

What is Endoxifen?

Chemical properties

Off-White to Pink Solid

The Uses of Endoxifen

A novel active metabolite of the anti-cancer drug Tamoxifen. It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast ca

The Uses of Endoxifen

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.

What are the applications of Application

(Z)-4-Hydroxy-N-desmethyl Tamoxifen (mixture of isomers) is a novel metabolite of tamoxifen

Definition

ChEBI: 4-Hydroxy-N-desmethyltamoxifen is a stilbenoid.

Properties of Endoxifen

Melting point:	127-129°C
Boiling point:	519.3±50.0 °C(Predicted)
Density	1.099±0.06 g/cm3(Predicted)
storage temp.	Amber Vial, -86°C Freezer, Under Inert Atmosphere
solubility	DMSO : 50 mg/mL (133.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	Powder
pka	10.36±0.15(Predicted)
color	White to off-white
Stability:	Light Sensitive, Temperature Sensitive

Safety information for Endoxifen

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H361:Reproductive toxicity H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.