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HomeProduct name listEltanolone

Eltanolone

Synonym(s):3α-Hydroxy-5β-pregnan-20-one;3α-Hydroxy-5β-tetrahydroprogesterone;Pregnanolone

  • CAS NO.:128-20-1
  • Empirical Formula: C21H34O2
  • Molecular Weight: 318.49
  • MDL number: MFCD00067137
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
Eltanolone Structural

What is Eltanolone?

The Uses of Eltanolone

A hyponotic-anaesthetic agent

The Uses of Eltanolone

A hyponotic-anaesthetic agent.

What are the applications of Application

5β-Pregnan-3α-ol-20-one is a simple derivitized steroid

Definition

ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

storage

Store at RT

Properties of Eltanolone

Melting point: 149°C
Boiling point: 397.64°C (rough estimate)
alpha  D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)
Density  1.0234 (rough estimate)
refractive index  1.5344 (estimate)
storage temp.  Store at RT
solubility  Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form  Solid
pka 15.12±0.70(Predicted)
color  White to Off-White
Water Solubility  8mg/L(room temperature)
NIST Chemistry Reference 3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)

Safety information for Eltanolone

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
Precautionary Statement Codes P281:Use personal protective equipment as required.

Computed Descriptors for Eltanolone

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