Eltanolone

Synonym(s):3α-Hydroxy-5β-pregnan-20-one;3α-Hydroxy-5β-tetrahydroprogesterone;Pregnanolone

CAS NO.：128-20-1
Empirical Formula: C21H34O2
Molecular Weight: 318.49
MDL number: MFCD00067137
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

What is Eltanolone?

The Uses of Eltanolone

A hyponotic-anaesthetic agent

The Uses of Eltanolone

A hyponotic-anaesthetic agent.

What are the applications of Application

5β-Pregnan-3α-ol-20-one is a simple derivitized steroid

Definition

ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

storage

Store at RT

Properties of Eltanolone

Melting point:	149°C
Boiling point:	397.64°C (rough estimate)
alpha	D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)
Density	1.0234 (rough estimate)
refractive index	1.5344 (estimate)
storage temp.	Store at RT
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Solid
pka	15.12±0.70(Predicted)
color	White to Off-White
Water Solubility	8mg/L(room temperature)
NIST Chemistry Reference	3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)

Safety information for Eltanolone

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity
Precautionary Statement Codes	P281:Use personal protective equipment as required.